Wednesday, March 01, 2006

Re: st: Re: assigning household characteristics to an individual with missing values

On 3/2/06, Friedrich Huebler <> wrote: > Out of curiosity, what kind of data has households in which everyone > is either a father, mother, son, or daughter?

I've no idea if this is the case here (and strongly doubt it is), but such data is collected under a study design called the Transmission Disequilibrium Test (TDT), where the investigator is interested in distortions in the ratio of alleles transmitted from the parents to off-spring (who will in such cases be affected by some sort of disease).

Its a test for linkage and association and was first proposed by...

Spielmen, McGinnis & Ewens (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (iddm). American Journal of Human Genetics 52(3):506-516

...and has undergone a number of extensions and developments, to account missing parents, quantitative traits, and so forth, although for such a test whether some one is considered the 'household head' is irrelevant.

The test has even been implemented in Stata...

. findit tdt

Neil -- "There is always an easy solution to every...problem - neat, plausible, and wrong." - H. L. Mencken

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