Tuesday, March 21, 2006

st: Meta-analysis of diagnostic tests

Has anybody used Stata to do a meta-analysis of diagnostic tests? Specifically, I would like to generate summary positive and negative likelihood ratios with p-values, and an associated test of heterogeneity. I am not convinced that the metan command (metan tp fn fp tn, with tp=true positive, fn=false negative, etc.), as some have suggested, produces correct results.

As a (less desirable) alternative, I believe that I can use a logit command to generate a summary sensitivity/specificity. However, I am unclear on how that would actually be coded.

Any advice on either approach would be MUCH appreciated.

Thanks very much,

Hilary Seligman hseligman@medsfgh.ucsf.edu

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